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found that CBP (cAMP-responsive element-binding (CREB)-binding protein) and SIRT4 in PDAC cells bind the K44 site of BCAT2 to acetylate this site, which further promotes the degradation of BCAT2 through the ubiquitin-protein pathway, reduces the metabolic rate of BCAAs in PDAC, and, in turn, inhibits the growth of tumor cells

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Limit chocolate, caffeine, alcohol, high-fat foods, and spicy dishes, as these relax the lower esophageal sphincter

Araujo AQ, Silva MT

9 Nutrients Note: In addition to reviewing the integrative interventions described here, readers are encouraged to review those described in the Immune Senescence protocol